How Do Grains Cause a Leaky Gut? A Better Guide (2024)

You might have encountered the term “leaky gut,” sometimes called increased intestinal permeability, in your search for health information.

While the scientific community has traditionally not given much attention to this topic, numerous nutritional and naturopathic experts strongly believe that a leaky gut is intertwined with various health issues.

One area of particular interest revolves around the connection between leaky gut and grains, which are believed to play a role in this condition.

At all times, we adopt an evidence-based approach and strive to provide you with practical knowledge and tips to support your journey toward optimal health.

In the article, we’ll delve into the underlying factors contributing to a leaky gut and explore how this condition may be linked to our consumption of grains..

What is Leaky Gut?

How Do Grains Cause a Leaky Gut - Miller Reviews

Our remarkable digestive system consists of a protective layer of cells that acts as a crucial barrier between our internal environment & the outside world.

This barrier serves a vital purpose by permitting the passage of nutrients and water into our bloodstream while effectively blocking the entry of waste products and toxins into our precious bodies.

Spanning the length of the intestinal lining are minuscule gaps between cells, aptly named “tight junctions.”

A leaky gut arises when these tight junctions unexpectedly loosen, granting entry to substances that should otherwise be eliminated from our system.

These unwelcome intruders can encompass partially digested food particles, microorganisms, or even toxins, posing potential threats to our well-being.

How Do Grains Cause a Leaky Gut - Miller Reviews

Increased intestinal permeability has been associated with a multitude of health concerns, such as:

  • Autoimmune diseases such as coeliac disease
  • Irritable Bowel Syndrome (IBS)
  • Type 2 diabetes (1)
  • Food sensitivities
  • Migraine & headaches
  • Chronic fatigue & fibromyalgia
  • Depression & mood disorders and poor memory
  • Skin conditions
  • Increased inflammation
  • Thyroid abnormalities
  • Parkinson’s disease
  • Alzheimer’s disease
  • Poor nutrient absorption

What Causes Leaky Gut?

How Do Grains Cause a Leaky Gut - Miller Reviews

The expansion of gaps in tight junctions is driven by the secretion of a protein called zonulin, which is synthesized by our intestinal cells. Interestingly, the discovery of this substance is relatively recent, as it entered the realm of scientific knowledge in the year 2000.

Researchers are currently intrigued by the factors triggering the release of zonulin. According to numerous alternative health practitioners, a leaky gut may be a consequence of persistent inflammation.

While some studies have established a connection between the release of zonulin and increased inflammation, it remains challenging to determine the cause-and-effect relationship.

We do know that certain dietary choices, such as the consumption of sugar, processed foods, and alcohol, have been linked to heightened inflammation in the body. However, to establish a more direct association with zonulin, we may need to examine the role of grains more closely.

What are Grains?

How Do Grains Cause a Leaky Gut - Miller Reviews

First and foremost, let’s establish a clear understanding of what exactly constitutes a grain. Although this may initially seem like a simple query, it’s important to delve deeper into the matter.

Grain can be defined as the consumable fruit of a plant, typically characterized by its small size and firm exterior.

Grains are derived from grass-like crops and often grow in clusters atop the plant stem.

It’s essential to differentiate grains from seeds, as seeds serve as the plant’s embryo.

Within the grain, we find both the seed and the fruit, providing nourishment for the developing plant.

Grains can be categorized based on their gluten content, which distinguishes one type from another.

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Gluten grains include:

  • Wheat: This is the most prevalent variety of gluten grains and goes by several names, such as bulgur, couscous, orzo, durum wheat, or semolina.
  • Rye
  • Barley
  • Most oats: It’s worth noting that unless certified gluten-free, many commercially-produced oats may be contaminated with gluten-containing grains during the processing stage.
  • Spelled: An ancient form of wheat.
  • Kamut: Another ancient wheat grain, occasionally referred to as oriental wheat.
  • Triticale: This unique grain is actually a hybrid of wheat and rye.

Non-gluten grains include:

  • Corn or maize: These terms refer to the same crop, but the term “maize” is commonly used in the United States.
  •  Rice
  •  Sorghum: This ancient cereal grain is highly popular in Africa and Asia. It serves a similar purpose to wheat in various culinary applications.
  •  Oats (if certified gluten-free): Oats can be consumed without worry if they have obtained a gluten-free certification. However, it is important to ensure that they are grown in locations where wheat is not cultivated and are not contaminated with gluten during the processing phase. Unlike gluten, oats contain a protein called avenin.

Some seeds look like grains & they are prepared in the same way. They’re called pseudocereals, & include:

  • Millet: Although technically a seed, millet is often referred to as a gluten-free grain due to its grain-like characteristics. Cultivated for thousands of years, millet has a rich history and can be incorporated into various dishes.
  •  Teff: This pseudocereal boasts a delightful nutty flavor and holds a special place as a staple in Ethiopian cuisine.
  •  Amaranth: While commonly mistaken for a grain, amaranth actually comes from a distinct plant family and is a distant relative of spinach and Swiss chard. It has ancient origins and provides a unique addition to culinary creations.
  •  Buckwheat: Despite its name, buckwheat is unrelated to wheat. Instead, it belongs to a same family as rhubarb and sorrel. This pseudocereal presents a range of culinary possibilities and is known for its distinct character.
  •  Quinoa: Among the most well-known pseudocereals, quinoa is derived from the seeds of a plant called goosefoot. It offers a remarkable nutritional profile and has gained widespread popularity as a versatile ingredient.

A Word about Gluten

How Do Grains Cause a Leaky Gut - Miller Reviews

Consumption of gluten-containing grains, which has been a part of human diets for millennia, has become associated with health issues, particularly those related to digestive well-being. Modern diets are saturated with gluten grains, making it challenging to avoid gluten in everyday meals and snacks.

Wheat, in particular, is pervasive in processed foods like bread, pastries, sauces, ready meals, and breakfast cereals. Modern crop varieties, engineered for higher yields, may behave differently in our bodies, potentially leading to increased inflammation.

Additionally, non-organic grain crops are often treated with weed killers and pesticides, which can harm the gut lining. Glyphosate-containing herbicides have been found to disrupt beneficial gut bacteria, crucial for maintaining a healthy gut lining.

The Latin word “gluten,” meaning “glue,” accurately describes its sticky nature, both in bread-making and within our intestines, potentially hindering nutrient absorption. Gluten, consisting of proteins gliadin and glutenin, can trigger the release of zonulin, a protein associated with opening the tight junctions in the intestinal lining. However, genetics and specific cell receptors activated by genes influence the reaction to zonulin.


How Do Grains Cause a Leaky Gut - Miller Reviews

Even everyday foods can harbor substances that may pose harm to the body. These substances, known as anti-nutrients, include lectins—a type of protein found in grains like wheat, spelled corn, beans, and lentils.

Recent research indicates that lectins can contribute to inflammation, damage the gut lining, and hinder nutrient absorption. Notably, red kidney beans can be poisonous when insufficiently cooked due to their lectin content.

Wheat contains a particularly problematic type of lectin. It is possible that plants developed lectins as a defense mechanism against insect pests. From an evolutionary perspective, it makes sense for plant seeds to contain anti-nutrients, as their purpose is to grow into new plants rather than being consumed.

The key takeaway is to enjoy a varied diet in moderation. High-heat cooking destroys lectins, and methods like soaking, sprouting, or fermenting grains and legumes can reduce lectin activity.

It’s important to recognize that individual tolerance to grains varies, influenced by our unique genetic makeup and lifestyle factors that shape gene expression and the impact of grains on our digestive system.

How can I Support a Leaky Gut? 

How Do Grains Cause a Leaky Gut - Miller Reviews

The juice cleans, whether at an Amchara retreat or in the comfort of your own home, can offer your body respite from grains, aiding in the reduction of inflammation and initiating the healing process in the gut.

In the long run, it can be beneficial to shift your perspective on grains, considering them as the occasional indulgence rather than a dietary staple.

Certain individuals may find that eliminating grains, especially gluten-containing ones like wheat, spelled, rye, and barley, improves well-being.

For optimal consumption, grains and legumes should be soaked or sprouted to decrease lectin activity.

While there is now a wide selection of “free from” food options available, it’s important to note that many of these alternatives contain food additives, preservatives, minimal fiber, and even added sugar, which can further harm the gut lining.

Adopting an anti-inflammatory eating plan is advisable, emphasizing vibrant fruits and vegetables, seeds, fresh nuts, & plant-based protein sources such as beans & lentils & oily fish while reducing intake of sugar, processed foods, red meat, and alcohol.


Understanding the relationship between grains and a leaky gut is crucial for optimizing our digestive wellness. While grains have been a dietary staple for centuries, modern cultivation practices, genetic modifications, and the presence of anti-nutrients like lectins have raised concerns about their impact on our gut health.

 We can support a healthier gut environment by adopting a mindful approach to grain consumption, such as enjoying them as occasional treats rather than daily necessities and employing techniques like soaking or sprouting to reduce lectin activity.

 Additionally, incorporating an anti-inflammatory eating plan rich in colorful fruits and vegetables, wholesome seeds and nuts, and plant-based proteins and minimizing processed foods, sugar, red meat, and alcohol can further promote gut healing and overall well-being. Armed with this knowledge, we can make informed choices that support optimal digestive health and pave the way for a vibrant and balanced lifestyle.


Why are grains often associated with a leaky gut? 

Grains, particularly gluten-containing varieties like wheat, spelled, rye, and barley, can contribute to a leaky gut due to various factors. These include the presence of lectins, which can damage the gut lining and impede nutrient absorption, as well as the potential for gluten to trigger an immune response and stimulate the release of substances like zonulin that affect the integrity of the gut barrier.

How do lectins in grains impact gut health? 

Lectins, the type of protein found in grains, beans, and lentils, have been linked to inflammation and gut lining damage. They can interfere with the absorption of nutrients and, in some cases, even be toxic if not properly cooked. However, cooking at high heat or using methods like soaking, sprouting, or fermenting grains and legumes can help reduce the activity of lectins and mitigate their potential negative effects.

Are all grains problematic for a leaky gut? 

Not all grains pose the same level of concern for a leaky gut. While gluten-containing grains like wheat are often singled out, some individuals may also experience sensitivities to other grains. Listening to your body & paying attention to any adverse reactions or symptoms when consuming grains is important. Some people find that eliminating grains or specific types of grains can alleviate gut issues and improve overall well-being.

Can a grain-free or gluten-free diet benefit those with a leaky gut? 

A grain-free or gluten-free diet may offer relief for individuals with leaky gut or digestive issues. By eliminating grains that are potentially problematic, it allows the gut to heal and reduces the burden on the digestive system. However, it’s important to ensure a balanced diet and obtain necessary nutrients from other sources, such as fruits, vegetables, lean proteins, and alternative grains or pseudocereals like millet, quinoa, or amaranth.

What other dietary considerations are important for a healthy gut? 

Whole grains can play a role in gut health; they are just one piece of the puzzle. Adopting an overall anti-inflammatory eating plan is beneficial for promoting a healthy gut. This includes consuming a variety of colorful fruits and vegetables, incorporating fiber-rich foods, such as seeds and nuts, prioritizing plant-based proteins like beans and lentils, and limiting processed foods, added sugars, red meat, and alcohol. Additionally, staying hydrated, managing stress levels, and supporting a diverse and balanced gut microbiome through probiotics and fermented foods are essential for overall gut health.

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